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MES-d13 is the deuterium labeled MES, an amphoteric ion buffer with a buffer capacity ranging from pH 5.5-7.0. It serves as a Good's buffer, widely utilized in various biochemistry and molecular biology experiments. This compound can be used as a tracer and as an internal standard for quantitative analysis.
Widely used in cell culture, enzyme activity determination, electrophoresis, and protein studies.
Can be used as a tracer for quantitation during drug development.
Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
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Sphingosine-1-phosphate (CAS 26993-30-6) is an endogenous signaling lipid functioning as a second messenger and ligand for the G-protein-coupled receptor S1PR1 (also called EDG1) It modulates diverse cellular processes including proliferation survival migration and vascular morphogenesis via activation of downstream pathways such as ERK-1/2 kinase and Gi protein-mediated signaling In cell-based assays S1P exhibits high-affinity binding (Kd 8 1 nM) to S1PR1 and induces calcium mobilization with an EC50 of approximately 2 nM Due to its roles in platelet function cell survival and vascular biology S1P is widely investigated in cell signaling research and therapeutic development
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